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<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">HBG1</span></h1>
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<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><table class="wikitable hintergrundfarbe-basis infobox float-right" id="Vorlage_Infobox_Protein_" style="font-size:90%; margin-top:0; width:350px;" summary="Infobox Protein">
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<th colspan="3" style="background:#90EE90; color:#202122;">HBG1
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<td colspan="3"><span typeof="mw:File"></span>
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<td colspan="3" class="hintergrundfarbe1" style="text-align:center; font-size:smaller; font-weight:bold;">Struktur des HBG1-Proteins
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<th colspan="3" style="background:#90EE90; color:#202122;">Bezeichner
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<td>Gen-Name(n)
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<td colspan="2" class="" style="text-align:center;">HBG1, HBGA, HBGR, HSGGL1
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<td>Externe IDs
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<td colspan="2" class="">
<ul><li><a href="Online_Mendelian_Inheritance_in_Man" title="Online Mendelian Inheritance in Man">OMIM</a>: <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/omim/142200">142200</a></li></ul>
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</p><p>Die <a href="Protein-Untereinheit" title="Protein-Untereinheit">Untereinheit</a> <b>Hemoglobin gamma-1</b> ist ein <a href="Protein" title="Protein">Protein</a>, für welches das beim Menschen vorhandene HBG1-<a href="Gen" title="Gen">Gen</a> codiert.<sup id="cite_ref-pmid2649166_1-0" class="reference"><a href="#cite_note-pmid2649166-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Funktion">Funktion</h2></div>
<p>Die gammaglobin-Gene (HBG1 und HBG2) äußern sich normalerweise in der <a href="F%C3%B6tal" class="mw-redirect" title="Fötal">fötalen</a> <a href="Leber" title="Leber">Leber</a>, <a href="Milz" title="Milz">Milz</a> und <a href="Knochenmark" title="Knochenmark">Knochenmark</a>. Zwei gamma-Ketten bilden zusammen mit zwei alpha-Ketten das fötale Hämoglobin (<a href="HbF" class="mw-redirect" title="HbF">HbF</a>), welches bei der Geburt normalerweise durch das Hämoglobin Erwachsener (<a href="H%C3%A4moglobin_A" class="mw-redirect" title="Hämoglobin A">HbA</a>) ersetzt wird. Bei einigen beta-<a href="Thalass%C3%A4mie" title="Thalassämie">Thalassämien</a> und den damit verbundenen Bedingungen dauert die Produktion von gamma-Ketten auch noch im Erwachsenenalter an. Die zwei Arten von gamma-Ketten unterscheiden sich bei Residuum 136, wo man bei der G-gamma-Produktion (HBG2) <a href="Glycin" title="Glycin">Glycin</a> und bei der A-gamma-Produktion (HBG1) <a href="Alanin" title="Alanin">Alanin</a> vorfindet. Ersteres ist bei der Geburt <a href="Dominanz_(Genetik)" title="Dominanz (Genetik)">prädominant</a>. Die Reihenfolge der Gene im beta-globin <a href="Gen-Cluster" title="Gen-Cluster">Cluster</a> lautet: 5' - <a href="HBE1" class="mw-redirect" title="HBE1">ε</a> – <a href="HBG2" title="HBG2">γ-G</a> – γ-A – <a href="HBD_(Protein)" class="mw-redirect" title="HBD (Protein)">δ</a> – <a href="%CE%92-Globin" title="Β-Globin">β</a> - 3'.<sup id="cite_ref-2" class="reference"><a href="#cite_note-2"><span class="cite-bracket">[</span>2<span class="cite-bracket">]</span></a></sup>
</p>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-pmid2649166-1"><span class="mw-cite-backlink"><a href="#cite_ref-pmid2649166_1-0">↑</a></span> <span class="reference-text">Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ: <cite class="lang" lang="en" dir="auto" style="font-style:italic">A review of the molecular genetics of the human alpha-globin gene cluster</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Blood_(Zeitschrift)" title="Blood (Zeitschrift)">Blood</a></cite>. 73. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5</span>, Mai 1989, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>1081–104</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/2649166?dopt=Abstract">PMID 2649166</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=A+review+of+the+molecular+genetics+of+the+human+alpha-globin+gene+cluster&rft.au=Higgs+DR%2C+Vickers+MA%2C+Wilkie+AO%2C+...&rft.date=1989-05&rft.genre=journal&rft.issue=5&rft.jtitle=Blood&rft.pages=1081-104&rft.pmid=2649166&rft.volume=73.+Jahrgang" style="display:none"> </span></span>
</li>
<li id="cite_note-2"><span class="mw-cite-backlink"><a href="#cite_ref-2">↑</a></span> <span class="reference-text"><span class="cite"><a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3047"><i>Entrez Gene: HBG1 hemoglobin, gamma A.</i></a><span class="Abrufdatum"> Abgerufen am 19. Mai 2012</span> (englisch).</span><span style="display: none;" class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2Fde.wikipedia.org%3AHBG1&rft.title=Entrez+Gene%3A+HBG1+hemoglobin%2C+gamma+A&rft.description=Entrez+Gene%3A+HBG1+hemoglobin%2C+gamma+A&rft.identifier=&rft.date=&rft.language=en"> </span></span>
</li>
</ol>
<div class="mw-heading mw-heading2"><h2 id="Literatur">Literatur</h2></div>
<ul><li>Huisman TH, Kutlar F, Gu LH: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Gamma chain abnormalities and gamma-globin gene rearrangements in newborn babies of various populations.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Hemoglobin</cite>. 15. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5</span>, 1992, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>349–79</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.3109/03630269108998857">10.3109/03630269108998857</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1802881?dopt=Abstract">PMID 1802881</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Gamma+chain+abnormalities+and+gamma-globin+gene+rearrangements+in+newborn+babies+of+various+populations.&rft.au=Huisman+TH%2C+Kutlar+F%2C+Gu+LH&rft.date=1992&rft.doi=10.3109%2F03630269108998857&rft.genre=journal&rft.issue=5&rft.jtitle=Hemoglobin&rft.pages=349-79&rft.pmid=1802881&rft.volume=15.+Jahrgang" style="display:none"> </span></li>
<li>Gelinas R, Yagi M, Endlich B, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Sequences of G gamma, A gamma, and beta genes of the Greek (A gamma) HPFH mutant: evidence for a distal CCAAT box mutation in the A gamma gene.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Prog. Clin. Biol. Res.</cite> 191. Jahrgang, 1985, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>125–39</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/2413469?dopt=Abstract">PMID 2413469</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Abook&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Sequences+of+G+gamma%2C+A+gamma%2C+and+beta+genes+of+the+Greek+%28A+gamma%29+HPFH+mutant%3A+evidence+for+a+distal+CCAAT+box+mutation+in+the+A+gamma+gene.&rft.au=Gelinas+R%2C+Yagi+M%2C+Endlich+B%2C+...&rft.btitle=Prog.+Clin.+Biol.+Res.&rft.date=1985&rft.genre=book&rft.pages=125-39&rft.pmid=2413469&rft.volume=191.+Jahrgang" style="display:none"> </span></li>
<li>Giardina B, Messana I, Scatena R, Castagnola M: <cite class="lang" lang="en" dir="auto" style="font-style:italic">The multiple functions of hemoglobin.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Crit. Rev. Biochem. Mol. Biol.</cite> 30. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>3</span>, 1995, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>165–96</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.3109/10409239509085142">10.3109/10409239509085142</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/7555018?dopt=Abstract">PMID 7555018</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=The+multiple+functions+of+hemoglobin.&rft.au=Giardina+B%2C+Messana+I%2C+Scatena+R%2C+...&rft.date=1995&rft.doi=10.3109%2F10409239509085142&rft.genre=journal&rft.issue=3&rft.jtitle=Crit.+Rev.+Biochem.+Mol.+Biol.&rft.pages=165-96&rft.pmid=7555018&rft.volume=30.+Jahrgang" style="display:none"> </span></li>
<li>Anderson NL, Anderson NG: <cite class="lang" lang="en" dir="auto" style="font-style:italic">The human plasma proteome: history, character, and diagnostic prospects.</cite> In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Mol. Cell Proteomics</cite>. 1. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>11</span>, 2003, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>845–67</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1074/mcp.R200007-MCP200">10.1074/mcp.R200007-MCP200</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/12488461?dopt=Abstract">PMID 12488461</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=The+human+plasma+proteome%3A+history%2C+character%2C+and+diagnostic+prospects.&rft.au=Anderson+NL%2C+Anderson+NG&rft.date=2003&rft.doi=10.1074%2Fmcp.R200007-MCP200&rft.genre=journal&rft.issue=11&rft.jtitle=Mol.+Cell+Proteomics&rft.pages=845-67&rft.pmid=12488461&rft.volume=1.+Jahrgang" style="display:none"> </span></li>
<li>Chang JC, Kan YW: <cite class="lang" lang="en" dir="auto" style="font-style:italic">beta 0 thalassemia, a nonsense mutation in man</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Proc._Natl._Acad._Sci._USA" class="mw-redirect" title="Proc. Natl. Acad. Sci. USA">Proc. Natl. Acad. Sci. USA</a></cite>. 76. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>6</span>, 1979, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>2886–9</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.76.6.2886">10.1073/pnas.76.6.2886</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/88735?dopt=Abstract">PMID 88735</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC383714/">PMC 383714</a> (freier Volltext) – (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=beta+0+thalassemia%2C+a+nonsense+mutation+in+man&rft.au=Chang+JC%2C+Kan+YW&rft.date=1979&rft.doi=10.1073%2Fpnas.76.6.2886&rft.genre=journal&rft.issue=6&rft.jtitle=Proc.+Natl.+Acad.+Sci.+USA&rft.pages=2886-9&rft.pmc=383714&rft.pmid=88735&rft.volume=76.+Jahrgang" style="display:none"> </span></li>
<li>Saglio G, Ricco G, Mazza U, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Human T gamma globin chain is a variant of A gamma chain (A gamma Sardinia)</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Proc. Natl. Acad. Sci. U.S.A.</cite> 76. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>7</span>, 1979, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>3420–4</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.76.7.3420">10.1073/pnas.76.7.3420</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/291015?dopt=Abstract">PMID 291015</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC383837/">PMC 383837</a> (freier Volltext) – (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Human+T+gamma+globin+chain+is+a+variant+of+A+gamma+chain+%28A+gamma+Sardinia%29&rft.au=Saglio+G%2C+Ricco+G%2C+Mazza+U%2C+...&rft.date=1979&rft.doi=10.1073%2Fpnas.76.7.3420&rft.genre=journal&rft.issue=7&rft.jtitle=Proc.+Natl.+Acad.+Sci.+U.S.A.&rft.pages=3420-4&rft.pmc=383837&rft.pmid=291015&rft.volume=76.+Jahrgang" style="display:none"> </span></li>
<li>Poon R, Kan YW, Boyer HW: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Sequence of the 3'-noncoding and adjacent coding regions of human gamma-globin mRNA</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Nucleic_Acids_Research" title="Nucleic Acids Research">Nucleic Acids Research</a>.</cite> 5. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>12</span>, 1979, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>4625–30</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/318163?dopt=Abstract">PMID 318163</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC342777/">PMC 342777</a> (freier Volltext) – (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Sequence+of+the+3%27-noncoding+and+adjacent+coding+regions+of+human+gamma-globin+mRNA&rft.au=Poon+R%2C+Kan+YW%2C+Boyer+HW&rft.date=1979&rft.genre=journal&rft.issue=12&rft.jtitle=Nucleic+Acids+Research.&rft.pages=4625-30&rft.pmc=342777&rft.pmid=318163&rft.volume=5.+Jahrgang" style="display:none"> </span></li>
<li>Grifoni V, Kamuzora H, Lehmann H, Charlesworth D: <cite class="lang" lang="en" dir="auto" style="font-style:italic">A new Hb variant: Hb F Sardinia gamma75(E19) isoleucine leads to threonine found in a family with Hb G Philadelphia, beta-chain deficiency and a Lepore-like haemoglobin indistinguishable from Hb A2</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Acta Haematol.</cite> 53. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>6</span>, 1975, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>347–55</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1159/000208204">10.1159/000208204</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/808940?dopt=Abstract">PMID 808940</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=A+new+Hb+variant%3A+Hb+F+Sardinia+gamma75%28E19%29+isoleucine+leads+to+threonine+found+in+a+family+with+Hb+G+Philadelphia%2C+beta-chain+deficiency+and+a+Lepore-like+haemoglobin+indistinguishable+from+Hb+A2&rft.au=Grifoni+V%2C+Kamuzora+H%2C+Lehmann+H%2C+...&rft.date=1975&rft.doi=10.1159%2F000208204&rft.genre=journal&rft.issue=6&rft.jtitle=Acta+Haematol.&rft.pages=347-55&rft.pmid=808940&rft.volume=53.+Jahrgang" style="display:none"> </span></li>
<li>Proudfoot NJ, Brownlee GG: <cite class="lang" lang="en" dir="auto" style="font-style:italic">3' non-coding region sequences in eukaryotic messenger RNA</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Nature" title="Nature">Nature</a></cite>. 263. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5574</span>, 1976, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>211–4</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/263211a0">10.1038/263211a0</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/822353?dopt=Abstract">PMID 822353</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=3%27+non-coding+region+sequences+in+eukaryotic+messenger+RNA&rft.au=Proudfoot+NJ%2C+Brownlee+GG&rft.date=1976&rft.doi=10.1038%2F263211a0&rft.genre=journal&rft.issue=5574&rft.jtitle=Nature&rft.pages=211-4&rft.pmid=822353&rft.volume=263.+Jahrgang" style="display:none"> </span></li>
<li>Marotta CA, Forget BG, Cohne-Solal M, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Human beta-globin messenger RNA. I. Nucleotide sequences derived from complementary RNA</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="J._Biol._Chem." class="mw-redirect" title="J. Biol. Chem.">J. Biol. Chem.</a></cite> 252. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>14</span>, 1977, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>5019–31</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/873928?dopt=Abstract">PMID 873928</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Human+beta-globin+messenger+RNA.+I.+Nucleotide+sequences+derived+from+complementary+RNA&rft.au=Marotta+CA%2C+Forget+BG%2C+Cohne-Solal+M%2C+...&rft.date=1977&rft.genre=journal&rft.issue=14&rft.jtitle=J.+Biol.+Chem.&rft.pages=5019-31&rft.pmid=873928&rft.volume=252.+Jahrgang" style="display:none"> </span></li>
<li>Frier JA, Perutz MF: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Structure of human foetal deoxyhaemoglobin</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">J. Mol. Biol.</cite> 112. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 1977, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>97–112</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/S0022-2836%2877%2980158-7">10.1016/S0022-2836(77)80158-7</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/881729?dopt=Abstract">PMID 881729</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Structure+of+human+foetal+deoxyhaemoglobin&rft.au=Frier+JA%2C+Perutz+MF&rft.date=1977&rft.doi=10.1016%2FS0022-2836%2877%2980158-7&rft.genre=journal&rft.issue=1&rft.jtitle=J.+Mol.+Biol.&rft.pages=97-112&rft.pmid=881729&rft.volume=112.+Jahrgang" style="display:none"> </span></li>
<li>Ahern E, Holder W, Ahern V, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Haemoglobin F Victoria Jubilee (alpha 2 A gamma 2 80 Asp-Try)</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Biochim._Biophys._Acta" class="mw-redirect" title="Biochim. Biophys. Acta">Biochim. Biophys. Acta</a></cite>. 393. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>1</span>, 1975, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>188–94</span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1138921?dopt=Abstract">PMID 1138921</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Haemoglobin+F+Victoria+Jubilee+%28alpha+2+A+gamma+2+80+Asp-Try%29&rft.au=Ahern+E%2C+Holder+W%2C+Ahern+V%2C+...&rft.date=1975&rft.genre=journal&rft.issue=1&rft.jtitle=Biochim.+Biophys.+Acta&rft.pages=188-94&rft.pmid=1138921&rft.volume=393.+Jahrgang" style="display:none"> </span></li>
<li>Waye JS, Cai SP, Eng B, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Clinical course and molecular characterization of a compound heterozygote for sickle hemoglobin and hemoglobin Kenya</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Am. J. Hematol.</cite> 41. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, 1993, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>289–91</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1002/ajh.2830410413">10.1002/ajh.2830410413</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1283810?dopt=Abstract">PMID 1283810</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Clinical+course+and+molecular+characterization+of+a+compound+heterozygote+for+sickle+hemoglobin+and+hemoglobin+Kenya&rft.au=Waye+JS%2C+Cai+SP%2C+Eng+B%2C+...&rft.date=1993&rft.doi=10.1002%2Fajh.2830410413&rft.genre=journal&rft.issue=4&rft.jtitle=Am.+J.+Hematol.&rft.pages=289-91&rft.pmid=1283810&rft.volume=41.+Jahrgang" style="display:none"> </span></li>
<li>Bailey WJ, Hayasaka K, Skinner CG, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Reexamination of the African hominoid trichotomy with additional sequences from the primate beta-globin gene cluster</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Mol. Phylogenet. Evol.</cite> 1. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, 1994, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>97–135</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1016/1055-7903%2892%2990024-B">10.1016/1055-7903(92)90024-B</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1342932?dopt=Abstract">PMID 1342932</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Reexamination+of+the+African+hominoid+trichotomy+with+additional+sequences+from+the+primate+beta-globin+gene+cluster&rft.au=Bailey+WJ%2C+Hayasaka+K%2C+Skinner+CG%2C+...&rft.date=1994&rft.doi=10.1016%2F1055-7903%2892%2990024-B&rft.genre=journal&rft.issue=2&rft.jtitle=Mol.+Phylogenet.+Evol.&rft.pages=97-135&rft.pmid=1342932&rft.volume=1.+Jahrgang" style="display:none"> </span></li>
<li>Gottardi E, Losekoot M, Fodde R, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Rapid identification by denaturing gradient gel electrophoresis of mutations in the gamma-globin gene promoters in non-deletion type HPFH</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Br. J. Haematol.</cite> 80. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>4</span>, 1992, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>533–8</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1111/j.1365-2141.1992.tb04569.x">10.1111/j.1365-2141.1992.tb04569.x</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1374633?dopt=Abstract">PMID 1374633</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Rapid+identification+by+denaturing+gradient+gel+electrophoresis+of+mutations+in+the+gamma-globin+gene+promoters+in+non-deletion+type+HPFH&rft.au=Gottardi+E%2C+Losekoot+M%2C+Fodde+R%2C+...&rft.date=1992&rft.doi=10.1111%2Fj.1365-2141.1992.tb04569.x&rft.genre=journal&rft.issue=4&rft.jtitle=Br.+J.+Haematol.&rft.pages=533-8&rft.pmid=1374633&rft.volume=80.+Jahrgang" style="display:none"> </span></li>
<li>Berry M, Grosveld F, Dillon N: <cite class="lang" lang="en" dir="auto" style="font-style:italic">A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic"><a href="Nature" title="Nature">Nature</a></cite>. 358. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>6386</span>, 1992, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>499–502</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/358499a0">10.1038/358499a0</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1379347?dopt=Abstract">PMID 1379347</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=A+single+point+mutation+is+the+cause+of+the+Greek+form+of+hereditary+persistence+of+fetal+haemoglobin&rft.au=Berry+M%2C+Grosveld+F%2C+Dillon+N&rft.date=1992&rft.doi=10.1038%2F358499a0&rft.genre=journal&rft.issue=6386&rft.jtitle=Nature&rft.pages=499-502&rft.pmid=1379347&rft.volume=358.+Jahrgang" style="display:none"> </span></li>
<li>Loudianos G, Moi P, Lavinha J, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Normal delta-globin gene sequences in Sardinian nondeletional delta beta-thalassemia</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Hemoglobin</cite>. 16. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>6</span>, 1993, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>503–9</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.3109/03630269208993118">10.3109/03630269208993118</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1487421?dopt=Abstract">PMID 1487421</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Normal+delta-globin+gene+sequences+in+Sardinian+nondeletional+delta+beta-thalassemia&rft.au=Loudianos+G%2C+Moi+P%2C+Lavinha+J%2C+...&rft.date=1993&rft.doi=10.3109%2F03630269208993118&rft.genre=journal&rft.issue=6&rft.jtitle=Hemoglobin&rft.pages=503-9&rft.pmid=1487421&rft.volume=16.+Jahrgang" style="display:none"> </span></li>
<li>Fucharoen S, Shimizu K, Fukumaki Y: <cite class="lang" lang="en" dir="auto" style="font-style:italic">A novel C-T transition within the distal CCAAT motif of the G gamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Nucleic Acids Res.</cite> 18. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>17</span>, 1990, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>5245–53</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1093/nar%2F18.17.5245">10.1093/nar/18.17.5245</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1698280?dopt=Abstract">PMID 1698280</a>, <a rel="nofollow" class="external text" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC332148/">PMC 332148</a> (freier Volltext) – (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=A+novel+C-T+transition+within+the+distal+CCAAT+motif+of+the+G+gamma-globin+gene+in+the+Japanese+HPFH%3A+implication+of+factor+binding+in+elevated+fetal+globin+expression&rft.au=Fucharoen+S%2C+Shimizu+K%2C+Fukumaki+Y&rft.date=1990&rft.doi=10.1093%2Fnar%2F18.17.5245&rft.genre=journal&rft.issue=17&rft.jtitle=Nucleic+Acids+Res.&rft.pages=5245-53&rft.pmc=332148&rft.pmid=1698280&rft.volume=18.+Jahrgang" style="display:none"> </span></li>
<li>Plaseska D, Kutlar F, Wilson JB, <i>et al.</i>: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Hb F-Jiangsu, the first gamma chain variant with a valine----methionine substitution: alpha 2A gamma 2 134(H12)Val----Met</cite>. In: <cite class="lang" lang="en" dir="auto" style="font-style:italic">Hemoglobin</cite>. 14. Jahrgang, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, 1991, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>177–83</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.3109/03630269009046959">10.3109/03630269009046959</a></span>, <a class="external mw-magiclink-pmid" rel="nofollow" href="https://www.ncbi.nlm.nih.gov/pubmed/1703137?dopt=Abstract">PMID 1703137</a> (englisch).<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:HBG1&rft.atitle=Hb+F-Jiangsu%2C+the+first+gamma+chain+variant+with+a+valine----methionine+substitution%3A+alpha+2A+gamma+2+134%28H12%29Val----Met&rft.au=Plaseska+D%2C+Kutlar+F%2C+Wilson+JB%2C+...&rft.date=1991&rft.doi=10.3109%2F03630269009046959&rft.genre=journal&rft.issue=2&rft.jtitle=Hemoglobin&rft.pages=177-83&rft.pmid=1703137&rft.volume=14.+Jahrgang" style="display:none"> </span></li></ul></div><!--htdig_noindex--><div><div class="zim-footer">
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